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PROGNOSTIC SIGNIFICANCE OF STRUMAL CALLA EXPRESSION IN PRIMARY BREAST CARCINOMA IN RELATION TO PATHOLOGICAL RSPONCE AFTER NEOADJUVANT CHEMOTHERAPY

Iftikhar K. Abbas Altemimi
Mais M Salim Mohammed Hasan
Binan Adil alaaragy
Roaa Hameed Alwaith
Zainab Nassir Dosh
Journal of Progressive Medical Sciences, Vol. 1 No. 2 (2025): Journal of Progressive Medical Sciences
Published: 2025-08-31

Abstract

Background: In this study we aimed to assess the IHC expression of stromal CALLA in invasive breast carcinomas as prognostic factor and correlate its relationship with six clinico-pathological parametrs by assessing the pathological response to neoadjuvant chemotherapy


Method: Study design is cross-sectional, it conducted on 50 females with breast invasive ductal carcinoma, FFPE tissue blocks collected from the archive of laboratory of Al-Sader medical city - Al Najaf governorate/ Iraq, during the period from September 2023 to September 2024. CALLA immunohistochemistry expression detected by labeled polymers and enhanced polymer system (Dako En-Vision™ Flex) Dako-protocol. it was correlated with age of patients, tumor grade, hormonal expression, her-2/neo expression, Ki-67 expression and molecular profile.


Result: Stromal CALLA immunohistochemistry was expressed in 48%. There is statistically significant positive correlations between stromal expression and response to neoadjuvant chemotherapy (P = 0.011), most cases with positive CALLA expression either nonresponding to NAC or achieved partial response while most of CALLA negative cases achieved complete pathological response the same for her-2 positive cases, though statistically non-significant but most CALLA expressed cases were Grade III, her-2 enriched and triple negative molecular profile most of them had partial pathological response (not complete)


Conclusions: Stromal CALLA had been expressed in 48% of invasive ductal carcinoma and there is positive correlation between stromal CALLA expressions and higher tumor grades, her-2 expression and triple negative profile suggesting the effects of stromal CALLA expression on aggressive behavior of breast ductal carcinoma with decreasing a chance of complete pathological response after neoadjuvant chemotherapy

Keywords

CALLA immunohistochemistry CD-10 breast carcinoma prognostic factor neoadjuvant chemotherapy molecular profile

How to Cite

1.
PROGNOSTIC SIGNIFICANCE OF STRUMAL CALLA EXPRESSION IN PRIMARY BREAST CARCINOMA IN RELATION TO PATHOLOGICAL RSPONCE AFTER NEOADJUVANT CHEMOTHERAPY. PMS [Internet]. 2025 Aug. 31 [cited 2026 Oct. 17];1(2). Available from: https://pms-journal.de/index.php/pms/article/view/23

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Author Biography

Iftikhar K. Abbas Altemimi
None
Mais M Salim Mohammed Hasan
None
Binan Adil alaaragy
None
Roaa Hameed Alwaith
None
Zainab Nassir Dosh
None
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How to Cite

1.
PROGNOSTIC SIGNIFICANCE OF STRUMAL CALLA EXPRESSION IN PRIMARY BREAST CARCINOMA IN RELATION TO PATHOLOGICAL RSPONCE AFTER NEOADJUVANT CHEMOTHERAPY. PMS [Internet]. 2025 Aug. 31 [cited 2026 Oct. 17];1(2). Available from: https://pms-journal.de/index.php/pms/article/view/23